GCM2
Sign in to saveAlso known as GCMB, hGCMb, glial cells missing homolog 2, HRPT4, glial cells missing transcription factor 2, FIH2
Chorion-specific transcription factor GCMb is a protein that in humans is encoded by the GCM2 gene.
Gene data
GCM2- Name
- GCM transcription factor 2
- Type
- protein-coding
- Aliases
- FIH2, GCMB, HRPT4, hGCMb
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 3490
- exact match
- identifiers.org/ncbigene/9247
- genomic end
- 10882041
- genomic start
- 10873456
- cytogenetic location
- 6p24.2
Sources (3)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Chorion-specific transcription factor GCMb is a protein that in humans is encoded by the GCM2 gene.
The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM]