SIGLEC5
Sign in to saveAlso known as CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5, sialic acid binding Ig like lectin 5
Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. SIGLEC5 has also been designated CD170 (cluster of differentiation 170).
Gene data
SIGLEC5- Name
- sialic acid binding Ig like lectin 5
- Type
- protein-coding
- Position
- 51,610,948–51,630,401 (−)
- Aliases
- CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5
- Ensembl
- ENSG00000268500
- RefSeq RNA
- NM_001384708.1, NM_001384709.1, NM_003830.4, XM_047446914.1, XM_047446915.1
- RefSeq protein
- NP_001371637.1, NP_001371638.1, NP_003821.1, XP_047302870.1, XP_047302871.1
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sialic acid binding Ig like lectin 5
- Symbol
- SIGLEC5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:51,610,948-51,630,401
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. SIGLEC5 has also been designated CD170 (cluster of differentiation 170).
==References==
Excerpted from Wikipedia’s “SIGLEC5” article, available under the CC BY-SA 4.0 licence.