siramesine
Sign in to saveSiramesine (or Lu 28-179) is a sigma receptor agonist, selective for the σ2 subtype. In animal studies, siramesine has been shown to produce anxiolytic and antidepressant effects. It was developed by the pharmaceutical company H Lundbeck for the treatment of anxiety, although development was discontinued after clinical trials showed a lack of efficacy in humans. Siramesine has been shown to produce an enhanced antidepressant effect when co-administered with NMDA antagonists. It has also been used to study the σ2 activity of cocaine, and has been shown to produce anticancer properties both in v
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 454.242
Show 3 more facts
- chemical formula
- C₃₀H₃₁FN₂O
- canonical SMILES
- C1CN(CCC12C3=CC=CC=C3CO2)CCCCC4=CN(C5=CC=CC=C54)C6=CC=C(C=C6)F
- Commons category
- Siramesine
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Encyclopedic overview
2 sectionsContents
- References
- External links
{{Drugbox | Verifiedfields = changed | verifiedrevid = 447773166 | IUPAC_name = 1'-{4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl}-3H-spiro[2-benzofuran-1,4'-piperidine] | image = Siramesine1.svg | image_class = skin-invert-image | width = 220 | image2 = Siramesine-3D.png | image_class2 = bg-transparent | width2 = 220
| tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration =
Excerpted from Wikipedia’s “siramesine” article, available under the CC BY-SA 4.0 licence.