SIRPB1
Sign in to saveAlso known as CD172b, SIRP-BETA-1, signal regulatory protein beta 1
Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene. SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).
Gene data
SIRPB1- Name
- signal regulatory protein beta 1
- Type
- protein-coding
- Aliases
- CD172b, SIRB1, SIRP-BETA-1
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
via MyGene.info
Gene · Ensembl
signal regulatory protein beta 1
- Symbol
- SIRPB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:1,561,385-1,620,061
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SIRPB1 PDB 2d9c.png
Show 8 more facts
- HomoloGene ID
- 82993
- exact match
- identifiers.org/ncbigene/10326
- found in taxon
- Homo sapiens
- genomic end
- 1600707
- genomic start
- 1561385
- chromosome
- human chromosome 20
- cytogenetic location
- 20p13
- expressed in
- lymph node
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene. SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.
Excerpted from Wikipedia’s “SIRPB1” article, available under the CC BY-SA 4.0 licence.