Sirtuina
Sign in to saveSirtuins are a family of signaling proteins involved in metabolic regulation. They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. Chemically, sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.
Wikidata facts
- Subclass of
- enzyme
Show 3 more facts
- found in taxon
- eukaryote
- subject has role
- ADP-ribosylation
- molecular function
- catalysis
Sources (2)
via Wikidata · CC0
Article · Español
Las sirtuinas son una clase de enzimas, concretamente histona deacetilasas NAD-dependientes, que se encuentran tanto en organismos procariotas como eucariotas. Afectan al metabolismo celular regulando la expresión de ciertos genes (epigenética) dentro de eucariotas (vegetales y animales). El nombre proviene de su nombre en Inglés, Silent mating type Information Regulation two, el gen responsable de la regulación celular en el interior de las levaduras, e -ina, terminación o sufijo convencional para las proteínas.
Abstract from DBpedia / Wikipedia · CC BY-SA