Sirtuína
Sign in to saveSirtuins are a family of signaling proteins involved in metabolic regulation. They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. Chemically, sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.
Wikidata facts
- Subclass of
- enzyme
Show 3 more facts
- found in taxon
- eukaryote
- subject has role
- ADP-ribosylation
- molecular function
- catalysis
Sources (2)
via Wikidata · CC0
Article · Português
As sirtuínas são uma classe de enzimas que processam a desacetilase das histonas ou a actividade da mono-ribosiltransferase. Encontram-se num grande espectro de organismos, desde as leveduras e bactérias aos humanos. As sirtuínas parecem estar relacionadas com o envelhecimento e na regulação da transcrição, apoptose e resistência ao stress, como também com regulação de processos metabólicos em situações de baixa quantidade de calorias.
Abstract from DBpedia / Wikipedia · CC BY-SA