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GeneQ18048128· pop 5· linked from 259 articles

SLC25A21

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Also known as ODC, ODC1, solute carrier family 25 member 21, MTDPS18

protein-coding gene in the species Homo sapiens

Gene data

SLC25A21

Name: solute carrier family 25 member 21
Type: protein-coding
Position: 36,677,921–37,172,743 (−)
Aliases: MTDPS18, ODC, ODC1
Ensembl: ENSG00000183032
RefSeq RNA: NM_001171170.2, NM_030631.4, XM_011537288.4, XM_011537289.4, XM_047431871.1
RefSeq protein: NP_001164641.1, NP_085134.1, XP_011535590.1, XP_011535591.1, XP_047287827.1

SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004].

Gene Ontology

Biological process

L-lysine catabolic process transmembrane transport mitochondrial alpha-ketoglutarate transmembrane transport mitochondrial alpha-ketoglutarate transmembrane transport

Molecular function

alpha-ketoglutarate transmembrane transporter activity alpha-ketoglutarate transmembrane transporter activity alpha-ketoglutarate transmembrane transporter activity

Cellular component

mitochondrion mitochondrial inner membrane mitochondrial inner membrane mitochondrial inner membrane

Pathways

Metabolism Lysine catabolism Metabolism of amino acids and derivatives

via MyGene.info

Gene · Ensembl

solute carrier family 25 member 21

Symbol: SLC25A21
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:36,677,921-37,172,743
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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via Wikidata sitelinks · CC0