SLC26A5

Also known as DFNB61, PRES, solute carrier family 26 member 5

Prestin is a protein that is critical to sensitive hearing in mammals. It is encoded by the SLC26A5 (solute carrier anion transporter family 26, member 5) gene.

In the Vinony graph

Vinony's link graph records 271 inbound references to SLC26A5, and connects out to Q180686, transmembrane transport proteins and Ensembl genome database project.

It is catalogued under topics including Genes on human chromosome 7 and Solute carrier family.

Vinony links it to 7 Wikipedia language editions.

Gene data

SLC26A5

Name: solute carrier family 26 member 5
Type: protein-coding
Position: 103,352,730–103,446,212 (−)
Aliases: DFNB61, PRES
Ensembl: ENSG00000170615
RefSeq RNA: NM_001167962.2, NM_001321787.2, NM_198999.3, NM_206883.3, NM_206884.3
RefSeq protein: NP_001161434.1, NP_001308716.1, NP_945350.1, NP_996766.1, NP_996767.1

This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009].

Pathways

Sensory processing of sound Sensory processing of sound by outer hair cells of the cochlea Sensory Perception

via MyGene.info

Gene · Ensembl

solute carrier family 26 member 5

Symbol: SLC26A5
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:103,352,730-103,446,212
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 69472
exact match: identifiers.org/ncbigene/375611
genomic end: 103446207
genomic start: 102993177
cytogenetic location: 7q22.1

Sources (5)

via Wikidata · CC0

~6 min read

Encyclopedic overview

8 sections

Contents

Function
Intrinsic voltage sensing
Anion transport
Discovery
Clinical significance
Blockers
References
Further reading

Prestin is a protein that is critical to sensitive hearing in mammals. It is encoded by the SLC26A5 (solute carrier anion transporter family 26, member 5) gene.

Different variants of this protein are known in the animal world, all involved in hearing or echolocation.

Excerpted from Wikipedia’s “SLC26A5” article, available under the CC BY-SA 4.0 licence.