SPINK1
Sign in to saveAlso known as PCTT, PSTI, Spink3, TATI, TCP, serine peptidase inhibitor, Kazal type 1, serine peptidase inhibitor Kazal type 1
Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded by the SPINK1 gene.
Gene data
SPINK1- Name
- serine peptidase inhibitor Kazal type 1
- Type
- protein-coding
- Position
- 147,824,572–147,831,679 (−)
- Aliases
- PCTT, PSTI, Spink3, TATI, TCP
- Ensembl
- ENSG00000164266
- RefSeq RNA
- NM_001354966.2, NM_001379610.1, NM_003122.5, XM_047417625.1, XM_047417626.1
- RefSeq protein
- NP_001341895.1, NP_001366539.1, NP_003113.2, XP_047273581.1, XP_047273582.1
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008].
Gene Ontology
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
serine peptidase inhibitor Kazal type 1
- Symbol
- SPINK1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:147,824,572-147,831,679
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SPINK1 PDB 1cgi.png
Show 9 more facts
- HomoloGene ID
- 68300
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6690
- genomic end
- 147831671
- genomic start
- 147824572
- chromosome
- human chromosome 5
- cytogenetic location
- 5q32
- expressed in
- pylorus
- genetic association
- chronic pancreatitis
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded by the SPINK1 gene.
Mutations in SPINK1 has been associated with hereditary pancreatitis and tropical pancreatitis. Trypsinogen is normally created and stored an inactive zymogen of trypsin in the pancreas, but occasionally will autoactivate itself. PSTI serves to cleave prematurely activated trypsin to prevent the enzyme from causing cellular damage to the organ. Without the function of PSTI, the pancreas is subject to repeated episodes of damage.
Excerpted from Wikipedia’s “SPINK1” article, available under the CC BY-SA 4.0 licence.