SPOP
Sign in to saveAlso known as BTBD32, TEF2, speckle type BTB/POZ protein, NEDMIDF, NSDVS1, NSDVS2, NEDMACE
Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.
Gene data
SPOP- Name
- speckle type BTB/POZ protein
- Type
- protein-coding
- Aliases
- BTBD32, NEDMACE, NEDMIDF, NSDVS1, NSDVS2, TEF2
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
- Image
- Protein SPOP PDB 2cr2.png
Show 5 more facts
- HomoloGene ID
- 68354
- exact match
- identifiers.org/ncbigene/8405
- genomic end
- 49678163
- genomic start
- 47676246
- cytogenetic location
- 17q21.33
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Article
4 sectionsContents
- DNA repair
- Clinical relevance
- References
- Further reading
Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.