SPRY4
Sign in to saveAlso known as HH17, sprouty RTK signaling antagonist 4
Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.
In the Vinony graph
Within Vinony's link graph, SPRY4 is referenced by 8 other articles, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.
It is catalogued under topics including Genes on human chromosome 5, Human proteins and SPR domain.
Its subject is documented across 5 Wikipedia language editions.
Gene data
SPRY4- Name
- sprouty RTK signaling antagonist 4
- Type
- protein-coding
- Position
- 142,310,420–142,326,455 (−)
- Aliases
- HH17
- Ensembl
- ENSG00000187678
- RefSeq RNA
- NM_001127496.3, NM_001293289.3, NM_001293290.3, NM_030964.5, XM_011537685.4
- RefSeq protein
- NP_001120968.1, NP_001280218.1, NP_001280219.1, NP_112226.2, XP_011535987.1
This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014].
Gene Ontology
Biological process
Cellular component
via MyGene.info
Gene · Ensembl
sprouty RTK signaling antagonist 4
- Symbol
- SPRY4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:142,310,420-142,326,455
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 8042
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/81848
- genomic end
- 141706020
- genomic start
- 141689992
- chromosome
- human chromosome 5
- cytogenetic location
- 5q31.3
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.
== Function ==
Excerpted from Wikipedia’s “SPRY4” article, available under the CC BY-SA 4.0 licence.