STAT5A

Name

signal transducer and activator of transcription 5A

Type

protein-coding

Position

42,287,547–42,311,943 (+)

Aliases

MGF, STAT5

Ensembl

ENSG00000126561

RefSeq RNA

NM_001288718.2, NM_001288719.2, NM_001288720.2, NM_001411103.1, NM_003152.4

RefSeq protein

NP_001275647.1, NP_001275648.1, NP_001275649.1, NP_001398032.1, NP_003143.2

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013].

via MyGene.info

Gene · Ensembl

signal transducer and activator of transcription 5A

Symbol

STAT5A

Biotype

Protein coding

Organism

Homo sapiens

Location

17:42,287,547-42,311,943

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein STAT5A PDB 1y1u.png

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