STEAP3
Sign in to saveAlso known as AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde, STEAP3 metalloreductase
Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene.
In the Vinony graph
Vinony's link graph records 3 inbound references to STEAP3, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
Vinony files it under EC 1.16.1 and Genes on human chromosome 2.
Vinony links it to 5 Wikipedia language editions.
Gene data
STEAP3- Name
- STEAP3 metalloreductase
- Type
- protein-coding
- Position
- 119,222,447–119,265,652 (+)
- Aliases
- AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde
- Ensembl
- ENSG00000115107
- RefSeq RNA
- NM_001008410.2, NM_018234.3, NM_138637.3, NM_182915.3, XM_011511403.2
- RefSeq protein
- NP_001008410.1, NP_060704.2, NP_619543.2, NP_878919.2, XP_011509705.1
This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
STEAP3 metalloreductase
- Symbol
- STEAP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:119,222,447-119,265,652
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein STEAP3 PDB 2VNS.png
Show 7 more facts
- HomoloGene ID
- 10084
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/55240
- genomic end
- 120023228
- genomic start
- 119981384
- chromosome
- human chromosome 2
- cytogenetic location
- 2q14.2
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene.
STEAP3 is a metalloreductase, capable of converting iron from an insoluble ferric (Fe3+) to a soluble ferrous (Fe2+) form.
Excerpted from Wikipedia’s “STEAP3” article, available under the CC BY-SA 4.0 licence.