MCM3AP

Also known as GANP, MAP80, SAC3, minichromosome maintenance complex component 3 associated protein, PNRIID

80 kDa MCM3-associated protein is a protein that in humans is encoded by the MCM3AP gene.

In the Vinony graph

Vinony's link graph records 5 inbound references to MCM3AP, and connects out to PubMed, human chromosome 21 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 21.

Vinony links it to 5 Wikipedia language editions.

Gene data

MCM3AP

Name: minichromosome maintenance complex component 3 associated protein
Type: protein-coding
Position: 46,232,689–46,286,617 (−)
Aliases: GANP, MAP80, PNRIID, SAC3
Ensembl: ENSG00000160294
RefSeq RNA: NM_003906.5, XM_005261203.5, XM_005261204.6, XM_005261205.5, XM_054324951.1
RefSeq protein: NP_003897.2, XP_005261260.1, XP_005261261.1, XP_005261262.1, XP_054180926.1

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014].