subtilisins

Also known as IPR034202, subtilisin

Subtilisin is a protease (a protein-digesting enzyme) initially obtained from Bacillus subtilis.

Key facts

Nonhuman protein.Organism: Bacillus amyloliquefaciens
Nonhuman protein.Name: Subtilisin BPN'
Nonhuman protein.image: Crystal structure of Subtilisin - 1st2.png
Nonhuman protein.caption: Crystal structure of subtilisin S8 domain.
Nonhuman protein.Symbol: apr
Nonhuman protein.CAS_number: 9014-01-1
Nonhuman protein.EntrezGene: 5712479
Nonhuman protein.PDB: 1st2
Nonhuman protein.PDB_supplemental: More structures
Nonhuman protein.UniProt: P00782
Nonhuman protein.ECnumber: 3.4.21.62
Nonhuman protein.footnotes: GO:0004252

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Wikidata facts

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EC enzyme number: 3.4.21.62
Commons category: Subtilisin

Sources (3)

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Article

9 sections

Contents

Nomenclature
Structure
Mechanism of catalysis
Applications
Research tool
Commercial
Occupational safety and health
See also
References

Subtilisin is a protease (a protein-digesting enzyme) initially obtained from Bacillus subtilis.

Subtilisins belong to subtilases, a group of serine proteases that – like all serine proteases – initiate the nucleophilic attack on the peptide (amide) bond through a serine residue at the active site. Subtilisins typically have molecular weights 27kDa. They can be obtained from certain types of soil bacteria, for example, Bacillus amyloliquefaciens from which they are secreted in large amounts.