Structure via PubChem · Public domain (PubChem)
sulconazole
Sign in to saveSulconazole (trade name Exelderm) is an antifungal medication of the imidazole class. It is available as a cream or solution to treat skin infections such as athlete's foot, ringworm, jock itch, and tinea versicolor. Although not used commercially for insect control, sulconazole nitrate exhibits a strong anti-feeding effect on the keratin-digesting Australian carpet beetle larvae Anthrenocerus australis.
Chemical data
- Formula
- C18H15Cl3N2S
- Molecular weight
- 397.7 g/mol
- IUPAC name
- 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole
- SMILES
- C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
- InChIKey
- AFNXATANNDIXLG-UHFFFAOYSA-N
- XLogP
- 6.1
- Polar surface area
- 43.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1985
- Admin. routes
- topical
via ChEMBL · EBI
Research
105 papers- Sulconazole.2006
- Sulconazole. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses.Drugs · 1988
- Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer.Molecular & cellular proteomics : MCP · 2023
- Sulconazole induces pyroptosis promoted by interferon-γ in monocyte/macrophage lineage cells.Journal of pharmacological sciences · 2024
- Sulconazole inhibits PD-1 expression in immune cells and cancer cells malignant phenotype through NF-κB and calcium activity repression.Frontiers in immunology · 2023
via PubMed
Wikidata facts
- Subclass of
- azole
- Mass
- 396.002153
Show 5 more facts
- chemical formula
- C₁₈H₁₅Cl₃N₂S
- canonical SMILES
- C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
- medical condition treated
- tinea pedis
- subject has role
- antifungal
- Commons category
- Sulconazole
via Wikidata · CC0
~2 min read
Encyclopedic overview
1 sectionsContents
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470472797 | IUPAC_name = 1-(2-{[(4-Chlorophenyl)methyl]sulfanyl}-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole | image = Sulconazole.svg | image_class = skin-invert-image
| tradename = Exelderm | Drugs.com = | MedlinePlus = a698018 | pregnancy_category = | legal_status = | routes_of_administration = Topical
Excerpted from Wikipedia’s “sulconazole” article, available under the CC BY-SA 4.0 licence.