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suriclone
Sign in to saveSuriclone (Suril) is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs. Other cyclopyrrolone drugs include zopiclone and pagoclone.
Chemical data
- Formula
- C20H20ClN5O3S2
- Molecular weight
- 478 g/mol
- IUPAC name
- [6-(7-chloro-1,8-naphthyridin-2-yl)-5-oxo-3,7-dihydro-2H-[1,4]dithiino[2,3-c]pyrrol-7-yl] 4-methylpiperazine-1-carboxylate
- SMILES
- CN1CCN(CC1)C(=O)OC2C3=C(C(=O)N2C4=NC5=C(C=C4)C=CC(=N5)Cl)SCCS3
- InChIKey
- RMXOUBDDDQUBKD-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 129 Ų
- H-bond donors
- 0
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
59 papers- Suriclone: a new anxiolytic drug.Progress in neuro-psychopharmacology & biological psychiatry · 1983
- Anxiolytic cyclopyrrolones zopiclone and suriclone bind to a novel site linked allosterically to benzodiazepine receptors.Molecular pharmacology · 1984
- Suriclone: a new cyclopyrrolone derivative recognizing receptors labeled by benzodiazepines in rat hippocampus and cerebellum.Journal of neurochemistry · 1983
- Suriclone and diazepam in the treatment of neurotic anxiety. A double-blind cross-over trial.Psychopharmacology · 1987
- Suriclone enhances the actions of chlorpromazine on human psychomotor performance but not on memory or plasma prolactin in healthy subjects.European journal of clinical pharmacology · 1994
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 477.07
Show 4 more facts
- Commons category
- Suriclone
- chemical formula
- C₂₀H₂₀ClN₅O₃S₂
- canonical SMILES
- CN1CCN(CC1)C(=O)OC2C3=C(C(=O)N2C4=NC5=C(C=C4)C=CC(=N5)Cl)SCCS3
- subject has role
- anxiolytic
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Suriclone (Suril) is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs. Other cyclopyrrolone drugs include zopiclone and pagoclone.
Suriclone has a very similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties but with less amnestic effects, and its chemical structure is quite different from that of the benzodiazepine drugs.
Excerpted from Wikipedia’s “suriclone” article, available under the CC BY-SA 4.0 licence.