Sympatholytic
Sign in to saveAlso known as Sympatholytic Agents, Sympatholytic Drugs, Sympathetic-Blocking Agents
A sympatholytic (sympathoplegic) drug is a medication that opposes the downstream effects of postganglionic nerve firing in effector organs innervated by the sympathetic nervous system (SNS). They are indicated for various functions; for example, they may be used as antihypertensives. They are also used to treat anxiety, such as generalized anxiety disorder, panic disorder and PTSD. In some cases, such as with guanfacine, they have also shown to be beneficial in the treatment of ADHD.
Research
57,101 papers- Central sympatholytic drugs.Journal of clinical hypertension (Greenwich, Conn.) · 2011
- Direct Vasodilators and Sympatholytic Agents.Journal of cardiovascular pharmacology and therapeutics · 2016
- Targeting Features of the Metabolic Syndrome Through Sympatholytic Effects of SGLT2 Inhibition.Current hypertension reports · 2022
- Sympatholytic therapy in primary hypertension: a user friendly role for the future.Journal of human hypertension · 2002
- Central sympatholytic drugs for the treatment of hypertension: back to the future?Journal of hypertension · 2004
via PubMed
~7 min read
Article
10 sectionsContents
- Mechanisms of action
- Medical uses
- Hypertension
- Anxiety
- Beta blockers
- Alpha2 adrenergic agonist
- Alpha blockers
- See also
- References
- External links
A sympatholytic (sympathoplegic) drug is a medication that opposes the downstream effects of postganglionic nerve firing in effector organs innervated by the sympathetic nervous system (SNS). They are indicated for various functions; for example, they may be used as antihypertensives. They are also used to treat anxiety, such as generalized anxiety disorder, panic disorder and PTSD. In some cases, such as with guanfacine, they have also shown to be beneficial in the treatment of ADHD.
==Mechanisms of action== Antiadrenergic agents inhibit the signals of epinephrine and norepinephrine. They are primarily postsynaptic adrenergic receptor antagonists (alpha and beta adrenergic receptor antagonists, or "blockers"), inhibiting the downstream cellular signaling pathways of adrenergic receptors. However, there are exceptions: guanfacine and clonidine are adrenergic agonists at the α2 receptor; since this receptor is located presynaptically, agonism at this receptor inhibits the presynaptic release of adrenaline and noradrenaline, preventing postsynaptic adrenergic receptor activation and downstream signaling.