آلفا-سینوکلئین

Also known as synuclein, alpha (non A4 component of amyloid precursor), synuclein alpha-140, truncated alpha synuclein, Non-A4 component of amyloid precursor, SNCA, Non-A beta component of AD amyloid, non A-beta component of AD amyloid, alpha-synuclein

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Protein · UniProt

Alpha-synuclein

Gene: SNCA
Organism: Homo sapiens (Human)
Length: 140 aa
Molecular mass: 14,460 Da
Evidence: 1: Evidence at protein level

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its mu…

3D-structureAcetylationAlternative splicingAlzheimer diseaseAmyloidCell projectionCopperCytoplasm

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Swiss-Prot (reviewed) · via UniProt