アルファ-シヌクレイン

Also known as synuclein, alpha (non A4 component of amyloid precursor), synuclein alpha-140, truncated alpha synuclein, Non-A4 component of amyloid precursor, SNCA, Non-A beta component of AD amyloid, non A-beta component of AD amyloid, alpha-synuclein

Alpha-synuclein (aSyn) is a protein that in humans is encoded by the SNCA gene. It is a neuronal protein involved in the regulation of synaptic vesicle trafficking and the release of neurotransmitters.

In the Vinony graph

Within Vinony's link graph, アルファ-シヌクレイン is referenced by 157 other articles, and connects out to synaptic vesicle, amino acid and plasma membrane.

It is catalogued under topics including Genes on human chromosome 4, Lewy body dementia and Membrane channels.

Its subject is documented across 19 Wikipedia language editions.

Protein · UniProt

Alpha-synuclein

Gene: SNCA
Organism: Homo sapiens (Human)
Length: 140 aa
Molecular mass: 14,460 Da
Evidence: 1: Evidence at protein level

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its mu…

3D-structureAcetylationAlternative splicingAlzheimer diseaseAmyloidCell projectionCopperCytoplasm

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

52 registered

UNKNOWN
Biomarker Analysis for GBA Associated Parkinson's DiseaseLysosomal and Rare Disorders Research and Treatment Center, Inc. · NCT03811496
PHASE1COMPLETED
A First-in-Human Study of Single and Multiple Doses of anle138b in Healthy SubjectsMODAG GmbH · NCT04208152
COMPLETED
Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson's DiseaseGWT-TUD GmbH · NCT03043768
UNKNOWN
Biomarkers in Parkinsonian SyndromesUniversity Hospital, Bordeaux · NCT02114242
EARLY_PHASE1RECRUITING
Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15University of Pennsylvania · NCT06032026
RECRUITING
Colonoscopic Detection of Phosphorylated Alpha-synuclein for Parkinson's DiagnosisCND Life Sciences · NCT07204652

via ClinicalTrials.gov

Wikidata facts

Instance of: protein
Part of: Synuclein

Show 3 more facts

Commons category: Alpha-synuclein
exact match: purl.uniprot.org/uniprot/P37840
found in taxon: Homo sapiens

Sources (4)

via Wikidata · CC0

Article · 日本語

α-シヌクレイン (あるふぁ-しぬくれいん) はSNCA 遺伝子によってエンコードされるアミノ酸140残基からなるタンパク質。このタンパクの断片が、アルツハイマー病に蓄積するアミロイド中の (主な構成成分であるアミロイドベータとは別の) 成分として発見され、もとのタンパク質がNACP (Non-Abeta component precursor 非アミロイド成分の前駆体) と命名された。後にこれがシビレエイ属のシヌクレインタンパクと相同であることがわかり、ヒトα-シヌクレインと呼ばれるようになった。 α-シヌクレインの蓄積は、パーキンソン病をはじめとする神経変性疾患 (いわゆるシヌクレイノパチー) の原因とされている。

Abstract from DBpedia / Wikipedia · CC BY-SA