TAS2R1
Sign in to saveAlso known as T2R1, TRB7, taste 2 receptor member 1
Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene. It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop. Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.
Gene data
TAS2R1- Name
- taste 2 receptor member 1
- Type
- protein-coding
- Position
- 9,627,347–9,712,378 (−)
- Aliases
- T2R1, TRB7
- Ensembl
- ENSG00000169777
- RefSeq RNA
- NM_001386348.1, NM_019599.3
- RefSeq protein
- NP_001373277.1, NP_062545.1
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
taste 2 receptor member 1
- Symbol
- TAS2R1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:9,627,347-9,712,378
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 10480
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/50834
- genomic end
- 9712490
- genomic start
- 9627347
- chromosome
- human chromosome 5
- cytogenetic location
- 5p15.31
- expressed in
- prefrontal cortex
Sources (4)
via Wikidata · CC0
~3 min read
Encyclopedic overview
12 sectionsContents
- Expression and function
- Extra-oral roles of TAS2Rs
- Extra-oral roles of TAS2R1
- Structure of TAS2R1 receptor
- Gene
- SNPs
- Transcription factors
- Mutagenesis data
- Ligands
- See also
- References
- Further reading
Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene. It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop. Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.
== Expression and function ==
Excerpted from Wikipedia’s “TAS2R1” article, available under the CC BY-SA 4.0 licence.