taurolidine
Sign in to saveTaurolidine is an antimicrobial that is used to prevent infections in catheters. Side effects and the induction of bacterial resistance is uncommon. It is also being studied as a treatment for cancer.
Chemical data
- Formula
- C7H16N4O4S2
- Molecular weight
- 284.4 g/mol
- IUPAC name
- 4-[(1,1-dioxo-1,2,4-thiadiazinan-4-yl)methyl]-1,2,4-thiadiazinane 1,1-dioxide
via PubChem
Research
433 papers- Taurolidine/Heparin Lock Solution and Catheter-Related Bloodstream Infection in Hemodialysis: A Randomized, Double-Blind, Active-Control, Phase 3 Study.Clinical journal of the American Society of Nephrology : CJASN · 2023
- Taurolidine and Heparin as Catheter Lock Solution for Central Venous Catheters in Hemodialysis.American journal of therapeutics · 2024
- Taurolidine lock solution for catheter-related bloodstream infections in pediatric patients: A meta-analysis.PloS one · 2020
- Taurolidine-induced Severe Anaphylaxis.Kidney medicine · 2025
- [Taurolidine, an antiseptic for the prevention of central venous catheter-related infections].Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- +284.061
Show 1 more fact
- P366
- medication
via Wikidata · CC0
Article
9 sectionsContents
- Medical uses
- Side effects
- Toxicology
- Pharmacology
- Mechanism of action
- Chemical properties
- History
- Research
- References
Taurolidine is an antimicrobial that is used to prevent infections in catheters. Side effects and the induction of bacterial resistance is uncommon. It is also being studied as a treatment for cancer.
It is derived from the endogenous amino acid derivative taurine. The putative method of action involves the metabolism of taurolidine to taurinamide and ultimately taurine and water, liberating formaldehyde that chemically reacts with the mureins in the bacterial cell wall and with the amino and hydroxyl groups of endotoxins and exotoxins. This reaction denatures the endotoxins and complex polysaccharide and lipopolysaccharide components of the bacterial cell wall and inactivates susceptible exotoxins.