Structure via PubChem · Public domain (PubChem)
tezampanel
Sign in to saveAlso known as LY-293,558, LY293558, tezampanel anhydrous
Tezampanel (, ) (developmental code names LY-293,558, LY-326,325, NGX-424) is a drug originally developed by Eli Lilly which acts as a competitive antagonist of the AMPA and kainate subtypes of the ionotropic glutamate receptor family, with selectivity for the GluR5 subtype of the kainate receptor. It has neuroprotective and anticonvulsant properties, the former of which may, at least in part, occur via blockade of calcium uptake into neurons.
Chemical data
- Formula
- C13H21N5O2
- Molecular weight
- 279.34 g/mol
- IUPAC name
- (3S,4aR,6R,8aR)-6-[2-(2H-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid
- SMILES
- C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CCC3=NNN=N3)C(=O)O
- InChIKey
- ZXFRFPSZAKNPQQ-YTWAJWBKSA-N
- XLogP
- -0.8
- Polar surface area
- 104 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- migraine disorder
via ChEMBL · EBI
Wikidata facts
- Subclass of
- carboxylic acid
- Mass
- 279.169525
Show 4 more facts
- chemical formula
- C₁₃H₂₁N₅O₂
- isomeric SMILES
- C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CCC3=NNN=N3)C(=O)O
- canonical SMILES
- C1CC2CNC(CC2CC1CCC3=NNN=N3)C(=O)O
- Commons category
- Tezampanel
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Tezampanel (, ) (developmental code names LY-293,558, LY-326,325, NGX-424) is a drug originally developed by Eli Lilly which acts as a competitive antagonist of the AMPA and kainate subtypes of the ionotropic glutamate receptor family, with selectivity for the GluR5 subtype of the kainate receptor. It has neuroprotective and anticonvulsant properties, the former of which may, at least in part, occur via blockade of calcium uptake into neurons.
Tezampanel has a range of effects which may be useful for medicinal purposes, as well as its applications in scientific research. It suppresses both the withdrawal symptoms from morphine and other opioids, and the development of tolerance, as well as having antihyperalgesic and analgesic effects in its own right. It also has anxiolytic effects in animal studies and has been suggested as a candidate for the treatment of anxiety in humans.
Excerpted from Wikipedia’s “tezampanel” article, available under the CC BY-SA 4.0 licence.