Thy-1 cell surface antigen
Sign in to saveAlso known as CDw90, thy-1 antigen, Thy-1 T-cell antigen, thy-1 membrane glycoprotein, THY1
Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. Thy-1 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons. Structural study of Thy-1 led to the foundation of the Immunoglobulin superfamily, of which it is the smallest member, and led to some of the initial biochemical description and characterization of a vertebrate GPI anchor and also the first demons
Protein · UniProt
Thy-1 membrane glycoprotein
- Gene
- THY1
- Organism
- Homo sapiens (Human)
- Length
- 161 aa
- Molecular mass
- 17,935 Da
- Evidence
- 1: Evidence at protein level
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain
Swiss-Prot (reviewed) · via UniProt
Research
5,080 papers- Thy-1 antigen: a ganglion cell specific marker in rodent retina.Neuroscience · 1984
- Human Thy-1: expression on the cell surface of neuronal and glial cells.Brain research · 1982
- Thy-1+ dendritic epidermal cells express T3 antigen and the T-cell receptor gamma chain.Proceedings of the National Academy of Sciences of the United States of America · 1987
- Human Thy-1 antigen: cell surface expression on early T and B lymphocytes.Immunology · 1983
- Transitory expression of Thy-1 antigen in immature B cell lines.Immunological investigations · 1992
via PubMed
~14 min read
Encyclopedic overview
21 sectionsContents
- Discovery and nomenclature
- The conserved gene and its alleles
- The Protein
- Glycosylation
- Expression
- Detailed expression of Thy-1
- Induction of Thy-1 expression
- Localization
- Function
- Role in cognition
- Axon growth regulation
- T-cell activation
- Cell death
- Antibody target for animal model of glomerulonephritis
- Tumor suppression
- Role in cell adhesion, extravasation, migration
- Modulating fibrosis
- Other roles
- Use in stem cell biology
- References
- External links
Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. Thy-1 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons. Structural study of Thy-1 led to the foundation of the Immunoglobulin superfamily, of which it is the smallest member, and led to some of the initial biochemical description and characterization of a vertebrate GPI anchor and also the first demonstration of tissue specific differential glycosylation.
== Discovery and nomenclature ==
Excerpted from Wikipedia’s “Thy-1 cell surface antigen” article, available under the CC BY-SA 4.0 licence.