TNFRSF21

Name

TNF receptor superfamily member 21

Type

protein-coding

Aliases

BM-018, CD358, DR6

This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013].

via MyGene.info

Gene · Ensembl

TNF receptor superfamily member 21

Symbol

TNFRSF21

Biotype

Protein coding

Organism

Homo sapiens

Location

6:47,231,531-47,310,006

Strand

Reverse (−)

Assembly

GRCh38