Structure via PubChem · Public domain (PubChem)
توراسماید
Sign in to saveAlso known as AC-4464, AC4464, BM-02015, N-(((1-methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide, 1-isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea, torsemide
Torasemide, also known as torsemide, is a diuretic medication used to treat fluid overload due to heart failure, kidney disease, and liver disease. It is a less preferred treatment for high blood pressure. It is taken by mouth or by injection into a vein.
Chemical data
- Formula
- C16H20N4O3S
- Molecular weight
- 348.4 g/mol
- IUPAC name
- N-[4-(3-methylanilino)pyridin-1-ium-3-yl]sulfonyl-N'-propan-2-ylcarbamimidate
- SMILES
- CC1=CC(=CC=C1)NC2=C(C=[NH+]C=C2)S(=O)(=O)NC(=NC(C)C)[O-]
- InChIKey
- NGBFQHCMQULJNZ-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 116 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1993
- Admin. routes
- oral, parenteral
- Indications
- cardiovascular disease, heart failure, preeclampsia, congestive heart failure
via ChEMBL · EBI
Research
698 papers- Torasemide in Hypertension and Heart Failure: Re-inventing Loop Diuretic Therapy?Current pharmaceutical design · 2021
- Torasemide versus furosemide in treatment of heart failure: A systematic review and meta-analysis of randomized controlled trials.Journal of evaluation in clinical practice · 2020
- Torasemide prolonged release.Drugs · 2009
- Torasemide. An update of its pharmacological properties and therapeutic efficacy.Drugs · 1995
- [Torasemide].Revista de medicina de la Universidad de Navarra · 1996
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 348.125612
- Has use
- medication
Show 6 more facts
- Commons category
- Torasemide
- chemical formula
- C₁₆H₂₀N₄O₃S
- canonical SMILES
- CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C
- World Health Organisation international non-proprietary name
- torasemide
- subject has role
- diuretic
- defined daily dose
- 15
via Wikidata · CC0