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TP-13
Sign in to saveTP-13 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a subtype-selective partial agonist at GABAA receptors, binding selectively to GABAA receptor complexes bearing α2 and α3 subunits. It has modest anticonvulsant activity although less than that of diazepam, and its main effect is likely to be selective anxiolytic action, as seen with other related α2/3-preferring agonists such as L-838,417.
Chemical data
- Formula
- C19H19N7O
- Molecular weight
- 361.4 g/mol
- IUPAC name
- 7-cyclobutyl-6-[(2-methyl-1,2,4-triazol-3-yl)methoxy]-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine
- SMILES
- CN1C(=NC=N1)COC2=NN3C(=NN=C3C4=CC=CC=C4)C=C2C5CCC5
- InChIKey
- VACJUKKURQMWHE-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 83 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 361.165108228
Show 3 more facts
- Commons category
- TP-13
- canonical SMILES
- Cn1ncnc1COc1nn2c(-c3ccccc3)nnc2cc1C1CCC1
- chemical formula
- C₁₉H₁₉N₇O
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
TP-13 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a subtype-selective partial agonist at GABAA receptors, binding selectively to GABAA receptor complexes bearing α2 and α3 subunits. It has modest anticonvulsant activity although less than that of diazepam, and its main effect is likely to be selective anxiolytic action, as seen with other related α2/3-preferring agonists such as L-838,417.
== References ==
Excerpted from Wikipedia’s “TP-13” article, available under the CC BY-SA 4.0 licence.