tramiprosate
Sign in to saveHomotaurine, also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS, is a natural sulfonic acid found in seaweed. It is analogous to taurine, but with an extra carbon in its chain. It has GABAergic activity, apparently by mimicking GABA, which it resembles.
Chemical data
- Formula
- C3H9NO3S
- Molecular weight
- 139.18 g/mol
- IUPAC name
- 3-azaniumylpropane-1-sulfonate
via PubChem
Research
209 papers- Tramiprosate.Drugs of today (Barcelona, Spain : 1998) · 2006
- A Review on Tramiprosate (Homotaurine) in Alzheimer's Disease and Other Neurocognitive Disorders.Frontiers in neurology · 2020
- A Review of Recent Advances in the Management of Alzheimer's Disease.Cureus · 2024
- Nutritional Supplements and Neuroprotective Diets and Their Potential Clinical Significance in Post-Stroke Rehabilitation.Nutrients · 2021
- The potential protective effect of tramiprosate (homotaurine) against Alzheimer's disease: a review.Aging clinical and experimental research · 2012
via PubMed
Article
3 sectionsContents
- Medical use
- Biochemical properties
- References
Homotaurine, also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS, is a natural sulfonic acid found in seaweed. It is analogous to taurine, but with an extra carbon in its chain. It has GABAergic activity, apparently by mimicking GABA, which it resembles.
Homotaurine was investigated in a Phase III clinical trial as a potential treatment for Alzheimer's disease (AD) that did not show efficacy. However, post-hoc analyses have shown positive and significant effects of homotaurine on secondary endpoints and subgroups of patients, including a reduction in hippocampal volume loss and lower decline in memory function in the overall cohort, as well as a reduction in global cognitive decline in APOE4 allele carriers, suggesting a disease-modifying effect. A study in cognitive impairment done in 2018 did show positive benefits.