transthyretin
Sign in to saveAlso known as epididymis luminal protein 111, Prealbumin, ATTR, TBPA, TTR, thyroxine-binding prealbumin, carpal tunnel syndrome 1, prealbumin, amyloidosis type I
Transthyretin (TTR or TBPA) is a transport protein in the plasma and cerebrospinal fluid that transports the thyroid hormone thyroxine (T4) and retinol to the liver. This is how transthyretin gained its name: transports thyroxine and retinol. The liver secretes TTR into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid.
Protein · UniProt
Transthyretin
- Gene
- TTR
- Organism
- Homo sapiens (Human)
- Length
- 147 aa
- Molecular mass
- 15,887 Da
- Evidence
- 1: Evidence at protein level
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain
Swiss-Prot (reviewed) · via UniProt
Research
15,342 papers- Transthyretin Amyloid Cardiomyopathy: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2019
- Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy.The New England journal of medicine · 2025
- Hereditary transthyretin amyloidosis: a model of medical progress for a fatal disease.Nature reviews. Neurology · 2019
- Early Increase in Serum Transthyretin by Acoramidis Independently Predicts Improved Survival in TTR Amyloid Cardiomyopathy.Journal of the American College of Cardiology · 2025
- Transthyretin amyloid cardiomyopathy: Evolving therapies, expanding hope.Progress in cardiovascular diseases · 2025
via PubMed
Clinical Trials
242 registered- NAUNKNOWNINAPEN Protocol for Impact of Breakfast ImprovementCentre Hospitalier de Meaux · NCT01342861
- UNKNOWNSystemic Transthyretin Amyloidosis: Carpal Tunnel Syndrome in a Portuguese PopulationUniversidade do Porto · NCT05409833
- RECRUITINGEarly Diagnosis of Age-Linked CArdiac TransThyRetin Amyloidosis by Selective Screening in Spinal Stenosis SurgeryPhilippe Debonnaire · NCT06101108
- APPROVED_FOR_MARKETINGATTR Expanded Access Program (EAP) by IonisIonis Pharmaceuticals, Inc. · NCT03400098
- TERMINATEDTransthyretin Amyloidosis Cardiomyopathy in Patients With HFpEF in RussiaAstraZeneca · NCT06338839
- ACTIVE_NOT_RECRUITINGA Retrospective Observational Study of Epidemiology and Outcomes in Transthyretin Amyloid Cardiomyopathy in GermanyPfizer · NCT07494656
Wikidata facts
- Instance of
- protein
Show 6 more facts
- biological process
- signal transduction
- cell component
- extracellular exosome
- physically interacts with
- tafamidis
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P02766
- Commons category
- Transthyretin (synonym: prealbumin)
via Wikidata · CC0
~7 min read
Encyclopedic overview
6 sectionsContents
- Binding affinities
- Structure
- Role in disease
- References
- Further reading
- External links
Transthyretin (TTR or TBPA) is a transport protein in the plasma and cerebrospinal fluid that transports the thyroid hormone thyroxine (T4) and retinol to the liver. This is how transthyretin gained its name: transports thyroxine and retinol. The liver secretes TTR into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid.
TTR was originally called prealbumin (or thyroxine-binding prealbumin) because it migrated faster than albumin on electrophoresis gels. Prealbumin was felt to be a misleading name, it is not a synthetic precursor of albumin. The alternative name TTR was proposed by DeWitt Goodman in 1981.
Excerpted from Wikipedia’s “transthyretin” article, available under the CC BY-SA 4.0 licence.