triiodothyronine

Also known as 3,5,3'-triodo-L-thyronine, Cytomel®, liothyronine sodium, T3, 3,3',5-triiodo-L-thyronine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Tresitope, 3,5,3'-Triiodo-L-thyronine

Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.

OverviewAI-generated

Triiodothyronine is a chemical compound with the formula C₁₅H₁₂I₃NO₄. Its IUPAC name is (2S)-2-azaniumyl-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate. The substance has a mass of 650.79 and a weight of 650.97. It possesses a logP value of 2.4 and a topological polar surface area of 97.2. The molecule contains two hydrogen bond donors and four hydrogen bond acceptors, with a net charge of 0.

The compound is associated with the category Liothyronine. It has been the subject of 36,157 publications indexed in PubMed. Additionally, the topic is referenced by 588 other encyclopedia articles.

Synthesized by Vinony from 18 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Chemical data

Formula: C15H12I3NO4
Molecular weight: 650.97 g/mol
IUPAC name: (2S)-2-azaniumyl-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
SMILES: C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)[O-])[NH3+])I)I)O
InChIKey: AUYYCJSJGJYCDS-LBPRGKRZSA-N
XLogP: 2.4
Polar surface area: 97.2 Å²
H-bond donors: 2
H-bond acceptors: 4
Formal charge: 0

via PubChem

Research

36,157 papers

via PubMed

~14 min read

Encyclopedic overview

22 sections

Contents

Production
Synthesis from T<sub>4</sub>
Direct synthesis
Mechanism of action
Transportation
Effects
Skeletal growth
Protein
Lipids
Heart
Development
Neurotransmitters
Physiological function
Measurement
Medical uses
Treatment of depressive disorders
Use as a fat loss supplement
Alternative medicine
History
See also
References
External links

Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.

Production of T3 and its prohormone thyroxine (T4) is activated by thyroid-stimulating hormone (TSH), which is released from the anterior pituitary gland. This pathway is part of a closed-loop feedback process: Elevated concentrations of T3, and T4 in the blood plasma inhibit the production of TSH in the anterior pituitary gland. As concentrations of these hormones decrease, the anterior pituitary gland increases production of TSH, and by these processes, a feedback control system stabilizes the level of thyroid hormones in the bloodstream.

Excerpted from Wikipedia’s “triiodothyronine” article, available under the CC BY-SA 4.0 licence.