trilostane
Sign in to saveAlso known as WIN 24,540, WIN-24540
Trilostane, sold under the brand name Vetoryl among others, is a medication which has been used in the treatment of Cushing's syndrome, Conn's syndrome, and postmenopausal breast cancer in humans. It was withdrawn for use in humans in the United States in the 1990s but was subsequently approved for use in veterinary medicine in the 2000s to treat Cushing's syndrome in dogs. It is taken by mouth.
Research
540 papers- Update on the use of trilostane in dogs.The Canadian veterinary journal = La revue veterinaire canadienne · 2018
- Trilostane: Beyond Cushing's Syndrome.Animals : an open access journal from MDPI · 2025
- Pre-trilostane and three-hour post-trilostane cortisol to monitor trilostane therapy in dogs.The Veterinary record · 2016
- Trilostane in advanced breast cancer.Expert opinion on pharmacotherapy · 2006
- Association between post-ACTH cortisol and trilostane dosage in dogs with pituitary-dependent hypercortisolism.Domestic animal endocrinology · 2024
via PubMed
~7 min read
Encyclopedic overview
16 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Synthesis
- History
- Society and culture
- Legal status
- Generic names
- Brand names
- Availability
- Veterinary uses
- References
Trilostane, sold under the brand name Vetoryl among others, is a medication which has been used in the treatment of Cushing's syndrome, Conn's syndrome, and postmenopausal breast cancer in humans. It was withdrawn for use in humans in the United States in the 1990s but was subsequently approved for use in veterinary medicine in the 2000s to treat Cushing's syndrome in dogs. It is taken by mouth.
==Medical uses== Trilostane has been used in the treatment of Cushing's syndrome (hypercortisolism), Conn's syndrome (hyperaldosteronism), and postmenopausal breast cancer in humans. When used to treat breast cancer, trilostane is administered in combination with a corticosteroid to prevent glucocorticoid deficiency.
Excerpted from Wikipedia’s “trilostane” article, available under the CC BY-SA 4.0 licence.
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