TRIM68

Also known as GC109, RNF137, SS-56, SS56, tripartite motif containing 68

Tripartite motif-containing protein 68 is a protein that in humans is encoded by the TRIM68 gene.

Gene data

TRIM68

Name: tripartite motif containing 68
Type: protein-coding
Aliases: GC109, RNF137, SS-56, SS56

This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a 'really interesting new gene' (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].

via MyGene.info

Wikidata facts

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HomoloGene ID: 9991
exact match: identifiers.org/ncbigene/55128
genomic start: 4619902
genomic end: 4608231
cytogenetic location: 11p15.4

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Tripartite motif-containing protein 68 is a protein that in humans is encoded by the TRIM68 gene.

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.