TRIP4
Sign in to saveAlso known as ASC-1, ASC1, HsT17391, ZC2HC5, SMABF1, thyroid hormone receptor interactor 4, MDCDC
Activating signal cointegrator 1 is a protein in humans that is encoded by the TRIP4 gene.
Gene data
TRIP4- Name
- thyroid hormone receptor interactor 4
- Type
- protein-coding
- Aliases
- ASC-1, ASC1, HsT17391, MDCDC, SMABF1, ZC2HC5
This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016].
via MyGene.info
Gene · Ensembl
thyroid hormone receptor interactor 4
- Symbol
- TRIP4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:64,387,748-64,458,653
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 9426
- exact match
- identifiers.org/ncbigene/9325
- genomic end
- 64747502
- genomic start
- 64679947
- cytogenetic location
- 15q22.31
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Interactions
- References
- Further reading
Activating signal cointegrator 1 is a protein in humans that is encoded by the TRIP4 gene.
==Interactions== TRIP4 has been shown to interact with Nuclear receptor coactivator 1.