tyrothricin
Sign in to saveTyrothricin is an antibiotic mixture which was isolated from Brevibacillus brevis by Rene Dubos in the late 1930s. It was later shown by Dubos and Rollin Hotchkiss to be a mixture of two different antibiotics: gramicidin and tyrocidine.
Research
3,598 papers- Tyrothricin--An underrated agent for the treatment of bacterial skin infections and superficial wounds?Die Pharmazie · 2016
- Bacitracin and tyrothricin.The Medical clinics of North America · 1970
- [Tyrothricin].Ugeskrift for laeger · 1949
- Following tyrothricin peptide production by Brevibacillus parabrevis with electrospray mass spectrometry.Biochimie · 2020
- Tyrothricin as an antibiotic.Archives of surgery (Chicago, Ill. : 1920) · 1948
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Tyrothricin is an antibiotic mixture which was isolated from Brevibacillus brevis by Rene Dubos in the late 1930s. It was later shown by Dubos and Rollin Hotchkiss to be a mixture of two different antibiotics: gramicidin and tyrocidine.
Both gramicidin and tyrocidine are short polypeptides which disrupt the cell membranes of some, primarily Gram-positive, bacteria. Tyrothricin and its component antibiotics are too toxic to be taken internally but are sometimes used as topical antibiotics.
Excerpted from Wikipedia’s “tyrothricin” article, available under the CC BY-SA 4.0 licence.
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