UBA3

Name

ubiquitin like modifier activating enzyme 3

Type

protein-coding

Position

69,053,972–69,080,408 (−)

Aliases

NAE2, UBE1C, hUBA3

Ensembl

ENSG00000144744

RefSeq RNA

NM_001363861.1, NM_003968.4, NM_198195.2, NM_198197.1, XM_011534210.2

RefSeq protein

NP_001350790.1, NP_003959.3, NP_937838.1, XP_011532512.1, XP_054204301.1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

ubiquitin like modifier activating enzyme 3

Symbol

UBA3

Biotype

Protein coding

Organism

Homo sapiens

Location

3:69,053,972-69,080,408

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein UBE1C PDB 1r4m.png

via Wikidata · CC0