UBA7
Sign in to saveAlso known as D8, UBA1B, UBE1L, UBE2, ubiquitin like modifier activating enzyme 7, UBE7
Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.
Gene data
UBA7- Name
- ubiquitin like modifier activating enzyme 7
- Type
- protein-coding
- Position
- 49,805,205–49,814,151 (−)
- Aliases
- D8, UBA1B, UBE1L, UBE2, UBE7
- Ensembl
- ENSG00000182179
- RefSeq RNA
- NM_003335.3
- RefSeq protein
- NP_003326.2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 2502
- exact match
- identifiers.org/ncbigene/7318
- genomic end
- 49813953
- genomic start
- 49805209
- cytogenetic location
- 3p21.31
Sources (3)
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.