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uncoupling protein 1
ProteinQ419493· pop 18· linked from 283 articles

uncoupling protein 1

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Also known as mitochondrial brown fat uncoupling protein 1, uncoupling protein 1 (mitochondrial, proton carrier), solute carrier family 25 member 7, thermogenin, UCP1

Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial carrier protein found in brown adipose tissue (BAT). It is used to generate heat by non-shivering thermogenesis, and makes a quantitatively important contribution to countering heat loss in babies which would otherwise occur due to their high surface area-volume ratio. Recent findings indicate that the UCP1 protein plays a crucial role in thermogenesis by catalyzing the dissipative production of heat through protons derived from NADH and FADH2. These electron carriers ar

Protein · UniProt

Mitochondrial brown fat uncoupling protein 1

Gene
UCP1
Organism
Homo sapiens (Human)
Length
307 aa
Molecular mass
33,005 Da
Evidence
1: Evidence at protein level

Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960, PubMed:28781081). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra…

3D-structureDiabetes mellitusIon channelIon transportMembraneMitochondrionMitochondrion inner membraneObesity
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Swiss-Prot (reviewed) · via UniProt

Research

4,988 papers

via PubMed

Clinical Trials

5 registered

via ClinicalTrials.gov

~11 min read

Encyclopedic overview

10 sections
Contents
  • Structure
  • Mechanism
  • HEAT cycle
  • Evolution
  • History
  • Clinical relevance
  • See also
  • References
  • Further reading
  • External links

Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial carrier protein found in brown adipose tissue (BAT). It is used to generate heat by non-shivering thermogenesis, and makes a quantitatively important contribution to countering heat loss in babies which would otherwise occur due to their high surface area-volume ratio. Recent findings indicate that the UCP1 protein plays a crucial role in thermogenesis by catalyzing the dissipative production of heat through protons derived from NADH and FADH2. These electron carriers are produced in the TCA cycle from the oxidation of acetyl-CoA, which comes from the breakdown of free fatty acids. Intriguingly, the acetyl-CoA products undergo a recycling process that facilitates their re-utilization, thereby sustaining the cycle known as the HEAT cycle.

==Structure== thumb|left|Structure of the human uncoupling protein The atomic structure of human uncoupling protein 1 UCP1 has been solved by cryogenic-electron microscopy. The structure has the typical fold of a member of the SLC25 family. UCP1 is locked in a cytoplasmic-open state by guanosine triphosphate in a pH-dependent manner, preventing proton leak.

Excerpted from Wikipedia’s “uncoupling protein 1” article, available under the CC BY-SA 4.0 licence.

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