Zinc finger antiviral protein (ZAP) or Zinc finger CCCH-type antiviral protein 1 is a protein that in humans is encoded by the ZC3HAV1 gene.
This gene encodes a CCCH-type zinc finger protein. This antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses, including Ebola virus, HIV and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep 2021].
via MyGene.info
Zinc finger antiviral protein (ZAP) or Zinc finger CCCH-type antiviral protein 1 is a protein that in humans is encoded by the ZC3HAV1 gene.
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by viruses by targeting viral RNA for degradation, inhibiting its translation as well as affecting programmed viral frameshifting. ZAP targets CpG rich RNA viral sequences. In addition to antiviral activities, ZAP has been reported to inhibit LINE and Alu retrotransposition.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).