Also known as ZBP, ZP1, ZPB, Zp-4, zona pellucida glycoprotein 4, ZPB2, ZP1B
Zona pellucida sperm-binding protein 4, ZP-4 or avilesine, named after its discoverer Manuel Avilés Sánchez is a protein that in humans is encoded by the ZP4 gene.
In the Vinony graph
Within Vinony's link graph, ZP4 is referenced by 4 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Its subject is documented across 6 Wikipedia language editions.
Gene data
ZP4- Name
- zona pellucida glycoprotein 4
- Type
- protein-coding
- Position
- 237,877,864–237,890,922 (−)
- Aliases
- ZBP, ZP1, ZP1B, ZPB, ZPB2, Zp-4
- Ensembl
- ENSG00000116996
- RefSeq RNA
- NM_021186.5
- RefSeq protein
- NP_067009.1
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
zona pellucida glycoprotein 4
- Symbol
- ZP4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:237,877,864-237,890,922
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 49661
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/57829
- chromosome
- human chromosome 1
- genomic start
- 238045705
- genomic end
- 238054094
- cytogenetic location
- 1q43
- expressed in
- pharynx
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Zona pellucida sperm-binding protein 4, ZP-4 or avilesine, named after its discoverer Manuel Avilés Sánchez is a protein that in humans is encoded by the ZP4 gene.
== Function ==
Excerpted from Wikipedia’s “ZP4” article, available under the CC BY-SA 4.0 licence.