Structure via PubChem · Public domain (PubChem)
(2RS,6RS)-clopamide
Sign in to saveAlso known as BRI327, clopamide, 4-chloro-N-(2,6-dimethyl-1-piperidinyl)-3-sulfamoylbenzamide
Clopamide (trade name Brinaldix) is a piperidine diuretic.
Chemical data
- Formula
- C14H20ClN3O3S
- Molecular weight
- 345.8 g/mol
- IUPAC name
- 4-chloro-N-(2,6-dimethylpiperidin-1-yl)-3-sulfamoylbenzamide
- SMILES
- CC1CCCC(N1NC(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N)C
- InChIKey
- LBXHRAWDUMTPSE-UHFFFAOYSA-N
- XLogP
- 2.3
- Polar surface area
- 101 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 345.091
Show 7 more facts
- significant drug interaction
- dronedarone
- chemical formula
- C₁₄H₂₀ClN₃O₃S
- canonical SMILES
- CC1CCCC(N1NC(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N)C
- subject has role
- diuretic
- World Health Organisation international non-proprietary name
- clopamide
- Commons category
- Clopamide
- defined daily dose
- 10
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Mechanism of action
- References
Clopamide (trade name Brinaldix) is a piperidine diuretic.
==Mechanism of action== Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the distal convoluted tubule (DCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.
Excerpted from Wikipedia’s “(2RS,6RS)-clopamide” article, available under the CC BY-SA 4.0 licence.
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