Structure via PubChem · Public domain (PubChem)
A-68930
Sign in to saveAlso known as A 68930, A 70108, A 70360, A-70108, A-70360, A70108, A70360
A-68930 is a synthetic compound that acts as a selective dopamine receptor D1 agonist. It is orally active and has antidepressant and anorectic effects in animals, producing wakefulness and tachycardia, but without stimulant effects, instead producing sedation. The difference in effects between A-68930 and other D1 agonists such as SKF-82958 may be due to their differing effects on the related D5 receptor.
Chemical data
- Formula
- C16H17NO3
- Molecular weight
- 271.31 g/mol
- IUPAC name
- (1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol
- SMILES
- C1[C@H](O[C@H](C2=C1C(=C(C=C2)O)O)CN)C3=CC=CC=C3
- InChIKey
- SUHGRZPINGKYNV-GJZGRUSLSA-N
- XLogP
- 1.5
- Polar surface area
- 75.7 Ų
- H-bond donors
- 3
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
67 papers- The Discovery of Novel Selective D1 Dopaminergic Agonists: A-68930, A-77636, A-86929, and ABT-413.International journal of medicinal chemistry · 2011
- DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model.Brain research bulletin · 2021
- Dopamine D1 receptor agonist A-68930 ameliorates Aβ(1-42)-induced cognitive impairment and neuroinflammation in mice.International immunopharmacology · 2020
- Cardiovascular and renal hemodynamic effects of A-68930 in the conscious dog: a comparison with fenoldopam.The Journal of pharmacology and experimental therapeutics · 1994
- A-68930, a novel, potent dopamine D1 receptor agonist: a microstructural analysis of its effects on feeding and other behaviour in the rat.Behavioural pharmacology · 1994
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 271.120843
Show 5 more facts
- chemical formula
- C₁₆H₁₇NO₃
- isomeric SMILES
- C1[C@H](O[C@H](C2=C1C(=C(C=C2)O)O)CN)C3=CC=CC=C3
- canonical SMILES
- C1C(OC(C2=C1C(=C(C=C2)O)O)CN)C3=CC=CC=C3
- subject has role
- dopamine agonist
- Commons category
- A-68930
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
A-68930 is a synthetic compound that acts as a selective dopamine receptor D1 agonist. It is orally active and has antidepressant and anorectic effects in animals, producing wakefulness and tachycardia, but without stimulant effects, instead producing sedation. The difference in effects between A-68930 and other D1 agonists such as SKF-82958 may be due to their differing effects on the related D5 receptor.
== References ==
Excerpted from Wikipedia’s “A-68930” article, available under the CC BY-SA 4.0 licence.