pentostatin

Also known as 2'-deoxycoformycin, deoxycoformycin, Nipent®, Pentostatine, Co-vidarabine, Pentostatina, Pentostatinum

Pentostatin (or 2′-deoxycoformycin, trade name Nipent, manufactured by SuperGen) is an anticancer chemotherapeutic drug.

Key facts

Drug.H: 16
Drug.N: 4
Drug.O: 4
Drug.Watchedfields: changed
Drug.verifiedrevid: 464198455
Drug.IUPAC_name: (R)-3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
Drug.image: Pentostatin structure.svg
Drug.image_class: skin-invert-image
Drug.width: 200
Drug.image2: Pentostatin ball-and-stick.png
Drug.image_class2: bg-transparent
Drug.width2: 200
Drug.tradename: Nipent
Drug.MedlinePlus: a692004
Drug.pregnancy_US: D
Drug.legal_CA: Rx-only
Drug.legal_UK: POM
Drug.legal_US: Rx-only

via Wikipedia infobox

Research

1,217 papers

via PubMed

Wikidata facts

Subclass of: alkaloid
Mass: 268.117
Has use: medication

Show 9 more facts

chemical formula: C₁₁H₁₆N₄O₄
World Health Organisation international non-proprietary name: pentostatin
medical condition treated: chronic lymphocytic leukemia
isomeric SMILES: C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC=NC[C@H]3O)CO)O
canonical SMILES: C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O
Commons category: Pentostatin
physically interacts with: Adenosine deaminase
legal status (medicine): boxed warning
significant drug interaction: (RS)-cyclophosphamide

Sources (5)

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Encyclopedic overview

8 sections

Contents

Medical uses
Mechanism of action
Production
Fermentation
Total synthesis
Natural occurrence
Natural analogues
References

Pentostatin (or 2′-deoxycoformycin, trade name Nipent, manufactured by SuperGen) is an anticancer chemotherapeutic drug.

== Medical uses == Pentostatin is used to treat hairy cell leukemia. It is given by intravenous infusion once every two weeks for three to six months.

Excerpted from Wikipedia’s “pentostatin” article, available under the CC BY-SA 4.0 licence.

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