pentostatin

Also known as 2'-deoxycoformycin, deoxycoformycin, Nipent®, Pentostatine, Co-vidarabine, Pentostatina, Pentostatinum

Pentostatin (or 2′-deoxycoformycin, trade name Nipent, manufactured by SuperGen) is an anticancer chemotherapeutic drug.

Key facts

Drug.H: 16
Drug.N: 4
Drug.O: 4
Drug.Watchedfields: changed
Drug.verifiedrevid: 464198455
Drug.IUPAC_name: (R)-3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
Drug.image: Pentostatin structure.svg
Drug.image_class: skin-invert-image
Drug.width: 200
Drug.image2: Pentostatin ball-and-stick.png
Drug.image_class2: bg-transparent
Drug.width2: 200
Drug.tradename: Nipent
Drug.MedlinePlus: a692004
Drug.pregnancy_US: D
Drug.legal_CA: Rx-only
Drug.legal_UK: POM
Drug.legal_US: Rx-only

via Wikipedia infobox

Research

1,217 papers

via PubMed

Wikidata facts

Mass: 268.117

Show 5 more facts

chemical formula: C₁₁H₁₆N₄O₄
World Health Organisation international non-proprietary name: pentostatin
isomeric SMILES: C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC=NC[C@H]3O)CO)O
canonical SMILES: C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O
Commons category: Pentostatin

Sources (5)

via Wikidata · CC0

~4 min read

Article

8 sections

Contents

Medical uses
Mechanism of action
Production
Fermentation
Total synthesis
Natural occurrence
Natural analogues
References

Pentostatin (or 2′-deoxycoformycin, trade name Nipent, manufactured by SuperGen) is an anticancer chemotherapeutic drug.

== Medical uses == Pentostatin is used to treat hairy cell leukemia. It is given by intravenous infusion once every two weeks for three to six months.