AKAP5
Sign in to saveAlso known as AKAP75, AKAP79, H21, A-kinase anchoring protein 5
A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.
Gene data
AKAP5- Name
- A-kinase anchoring protein 5
- Type
- protein-coding
- Aliases
- AKAP75, AKAP79, H21
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 15854
- exact match
- identifiers.org/ncbigene/9495
- genomic end
- 64941221
- genomic start
- 64932217
- cytogenetic location
- 14q23.3
Sources (3)
via Wikidata · CC0
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Article
5 sectionsContents
- Function
- Interactions
- References
- External links
- Further reading
A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.
== Function ==