allysine
Sign in to saveAllysine is a derivative of lysine that features a formyl group in place of the terminal amine. The free amino acid does not exist, but the allysine residue does. It is produced by aerobic oxidation of lysine residues by the enzyme lysyl oxidase. The transformation is an example of a post-translational modification. The semialdehyde form exists in equilibrium with a cyclic derivative. thumb|center|Conversion of lysine residue to allysine residue.|380px
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3 sectionsContents
- Biochemical reactions
- References
- Further reading
Allysine is a derivative of lysine that features a formyl group in place of the terminal amine. The free amino acid does not exist, but the allysine residue does. It is produced by aerobic oxidation of lysine residues by the enzyme lysyl oxidase. The transformation is an example of a post-translational modification. The semialdehyde form exists in equilibrium with a cyclic derivative. thumb|center|Conversion of lysine residue to allysine residue.|380px
==Biochemical reactions== Allysine is linked to L-lysine in reactions catalysed by saccharopine dehydrogenases. These interconvert them via saccharopine: