ConceptQ206901· pop 78· linked from 2,760 articles

esclerose lateral amiotrófica

Also known as ALS, Lou Gehrig's disease, motor neuron disease, bulbar, Lou Gehrig disease, Charcot disease, Amyotrophic lateral sclerosis, motor neurone disease, MND

doença neurodegenerativa rara com amiotrofia e paralisia progressiva

AI overview

ALS (also called Lou Gehrig's disease) is a rare and serious disease where nerve cells controlling voluntary muscles gradually die, causing progressive weakness and wasting of muscles throughout the body. Over time, people with ALS lose the ability to move, speak, eat, and breathe on their own, making it a terminal condition with no cure.

AI-generated from the Wikipedia summary — may contain errors.

In the Vinony graph

Within Vinony's link graph, esclerose lateral amiotrófica is referenced by 2,760 other articles, and connects out to TARDBP, magnetic resonance imaging and dyspnea.

It is catalogued under topics including Amyotrophic lateral sclerosis, Cytoskeletal defects and Diseases named after patients.

Its subject is documented across 76 Wikipedia language editions.

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Key facts

Medical condition.name: Amyotrophic lateral sclerosis
Medical condition.image: ALS Affected neurons and muscles.png
Medical condition.caption: Parts of the nervous system affected by ALS, causing progressive symptoms in skeletal muscles throughout the body
Medical condition.field: Neurology
Medical condition.symptoms: Early: Stiff muscles, muscle twitches, gradual increasing weakness Late: Difficulty in speaking, swallowing, and breathing; respiratory failure; Rare: frontotemporal dementia
Medical condition.complications: Falling; Respiratory failure; Pneumonia; Malnutrition
Medical condition.onset: 45–75 years
Medical condition.causes: Unknown (90% to 95%) or genetic (5% to 10%)
Medical condition.risks: Genetic risk factors, age, male sex, heavy metals, organic chemicals, smoking, electric shock, head injury
Medical condition.diagnosis: Clinical diagnosis of exclusion based on progressive symptoms of upper and lower motor neuron degeneration for which no other explanation can be found. Supportive evidence from electromyography, genetic testing, and neuroimaging
Medical condition.differential: Multifocal motor neuropathy, Kennedy's disease, hereditary spastic paraplegia, nerve compression syndrome, diabetic neuropathy, post-polio syndrome, myasthenia gravis, multiple sclerosis
Medical condition.treatment: Walker, wheelchair, non-invasive ventilation, feeding tube, augmentative and alternative communication, symptomatic management
Medical condition.medication: Riluzole, edaravone, tofersen, dextromethorphan/quinidine
Medical condition.prognosis: Life expectancy is highly variable, but typically 2–4 years after diagnosis
Medical condition.alt: Diagram of a human nervous system highlighting the brain, spinal cord, motor neurons, and muscles of the body affected by ALS

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Research

72,010 papers

[Amyotrophic lateral sclerosis (ALS) - diagnosis, course of disease and treatment options].ReviewDeutsche medizinische Wochenschrift (1946) · 2021Meyer TDOI: 10.1055/a-1562-7882
The epidemiology of ALS: a conspiracy of genes, environment and time.ReviewNature reviews. Neurology · 2013Al-Chalabi A, Hardiman ODOI: 10.1038/nrneurol.2013.203
Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques.ReviewInternational journal of molecular sciences · 2019van den Bos MAJ, Geevasinga N, Higashihara M et al.DOI: 10.3390/ijms20112818
Genetics of ALS - genes and modifier.ReviewCurrent opinion in neurology · 2025Menge S, Decker L, Freischmidt ADOI: 10.1097/WCO.0000000000001416
ALS.ReviewNeurology · 1996Jerusalem F, Pohl C, Karitzky J et al.DOI: 10.1212/wnl.47.6_suppl_4.218s
ALS molecular subtypes are a combination of cellular and pathological features learned by deep multiomics classifiers.Cell reports · 2025O'Neill K, Shaw R, Bolger I et al.DOI: 10.1016/j.celrep.2025.115402
Studying ALS: Current Approaches, Effect on Potential Treatment Strategy.ReviewAdvances in experimental medicine and biology · 2020Ustyantseva EI, Medvedev SP, Zakian SMDOI: 10.1007/978-3-030-41283-8_11
Access for ALL in ALS: A large-scale, inclusive, collaborative consortium to unlock the molecular and genetic mechanisms of amyotrophic lateral sclerosis.ReviewMuscle & nerve · 2024Berry JD, Paganoni S, Harms MB et al.DOI: 10.1002/mus.28244

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Wikidata facts

Instance of: symptom or sign
Subclass of: disease
Named after: Jean-Martin Charcot
Image: ALS Coronal.jpg

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NCI Thesaurus ID: C34373
Commons category: Amyotrophic lateral sclerosis
ICPC 2 ID: N99
drug or therapy used for treatment: edaravone
genetic association: OPTN
exact match: www.orpha.net/ORDO/Orphanet_803
topic's main category: Category:Amyotrophic lateral sclerosis
health specialty: neurology
nickname: Lou Gehrig's disease
ICD-9-CM: 335.20
external data available at URL: www.nanbyou.or.jp/entry/52
on focus list of Wikimedia project: WikiProject Medicine
afflicts: motor neuron
short name: ALS

Sources (14)

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Article · Português

A esclerose lateral amiotrófica (ELA), também conhecida como doença do neurônio motor e doença de Lou Gehrig, é uma doença que causa a morte dos neurônios de controle dos músculos voluntários. Alguns também usam o termo doença do neurônio motor para um grupo de condições de que ELA é o mais comum. ELA é caracterizada por rigidez muscular, espasmos musculares, e, gradualmente, aumento da fraqueza, devido aos músculos diminuindo de tamanho. Isto resulta em dificuldade de fala, deglutição, e, por fim, da respiração. A causa não é conhecida em 90% a 95% dos casos. Cerca de 5-10% dos casos são herdados a partir dos pais da pessoa. Cerca de metade destes casos genéticos são devido a um de dos dois genes específicos. O diagnóstico é baseado nos sinais e sintomas com testes feitos para descartar outras causas possíveis. Não há cura conhecida para a esclerose lateral amiotrófica. Um medicamento chamado Riluzol pode prolongar a vida por cerca de dois a três meses. Ventilação não-invasiva pode resultar na melhoria da qualidade e duração da vida. A doença pode afetar pessoas de qualquer idade, mas geralmente começa em torno dos 60 anos de idade e em casos herdados, em torno de 50 anos de idade. A sobrevivência média de início para a morte é de dois a quatro anos. Cerca de 10% sobrevivem mais de 10 anos. A maioria morre de insuficiência respiratória. Em grande parte do mundo, as taxas de ELA são desconhecidas. Na Europa e Estados Unidos, a doença afeta cerca de duas pessoas por 100 mil habitantes por ano. Descrições da doença datam de pelo menos 1824, por Charles Bell. Em 1869, a conexão entre os sintomas e os fatores de problemas neurológicos foi descrita pela primeira vez por Jean-Martin Charcot, que, em 1874, começou a usar o termo esclerose lateral amiotrófica. Ela tornou-se conhecida nos Estados Unidos no século XX, quando, em 1939, afetou o jogador de beisebol Lou Gehrig e mais tarde em todo o mundo ao afetar o astrofísico Stephen Hawking. Em 2014, vídeos do Desafio do Balde de Gelo tornou-se viral na internet e aumentou a conscientização pública sobre a condição.

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