Anisatin is an extremely toxic, insecticidally active component of the shikimi plant. The lethal dose is 1 mg/kg (i.p.) in mice. Symptoms begin to appear about 1–6 hours after ingestion, beginning with gastrointestinal ailments, such as diarrhea, vomiting, and stomach pain, followed by nervous system excitation, seizures, loss of consciousness, and respiratory paralysis, which is the ultimate cause of death.
Anisatin is an extremely toxic, insecticidally active component of the shikimi plant. The lethal dose is 1 mg/kg (i.p.) in mice. Symptoms begin to appear about 1–6 hours after ingestion, beginning with gastrointestinal ailments, such as diarrhea, vomiting, and stomach pain, followed by nervous system excitation, seizures, loss of consciousness, and respiratory paralysis, which is the ultimate cause of death.
== Role in the GABA system == The GABA system is an important site of action by a variety of chemicals, including alcohols, heavy metals, and insecticides. A study conducted on frog spinal cords and rat brains indicated that anisatin was a strong non-competitive GABA antagonist. Anisatin was shown to suppress GABA-induced signals, but when anisatin was added without GABA, there was no change in the signal. Anisatin was also found to share the same binding site as picrotoxinin, and did not cause additional suppression of GABA-induced signals in the presence of high concentrations of picrotoxinin.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).