ankyrin
Sign in to saveAnkyrins are a family of proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. The name is derived from the Greek word ἄγκυρα (ankyra) for "anchor".
Key facts
- Protein.Band
- 21
- Protein.Name
- ANK3, node of Ranvier
- Protein.caption
- Ribbon diagram of a fragment of the membrane-binding domain of ankyrin R.
- Protein.image
- Ankyrin R membrane-binding domain 1N11.png
- Protein.width
- 250
- Protein.HGNCid
- 494
- Protein.Symbol
- ANK3
- Protein.AltSymbols
- AnkyrinG
- Protein.EntrezGene
- 288
- Protein.OMIM
- 600465
- Protein.RefSeq
- NM_020987
- Protein.UniProt
- Q12955
- Protein.PDB
- 1N11
- Protein.Chromosome
- 10
- Protein.Arm
- q
- Protein.LocusSupplementaryData
- -q27
via Wikipedia infobox
Article
9 sectionsContents
- Structure
- Membrane protein recognition
- Subtypes
- ANK1
- ANK2
- ANK3
- See also
- References
- External links
Ankyrins are a family of proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. The name is derived from the Greek word ἄγκυρα (ankyra) for "anchor".
==Structure== Ankyrins contain four functional domains: an N-terminal domain that contains 24 tandem ankyrin repeats, a central domain that binds to spectrin, a death domain that binds to proteins involved in apoptosis, and a C-terminal regulatory domain that is highly variable between different ankyrin proteins.