aphidicolin
Sign in to saveAphidicolin is a tetracyclic diterpene antibiotic isolated from the fungus Cephalosporum aphidicola with antiviral and antimitotic properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. It is a specific inhibitor of DNA polymerase Alpha and Delta in eukaryotic cells and in some viruses (vaccinia and herpesviruses) and an apoptosis inducer in HeLa cells. Natural aphidicolin is a secondary metabolite of the fungus Nigrospora oryzae.
Research
2,607 papers- Aphidicolin Chemistry of the Deep-Sea-Derived Fungus Botryotinia fuckeliana MCCC 3A00494.Journal of natural products · 2019
- Control of cell division by aphidicolin without adverse effects upon resting cells.Arzneimittel-Forschung · 1985
- Akanthomins A-C, aphidicolin analogs from a fungus Akanthomyces sp., that inhibit cell cycle.Phytochemistry · 2023
- Aphidicolin selectively kills neuroblastoma cells in vitro.Cancer letters · 1992
- [Aphidicolin: a specific inhibitor of eukaryotic DNA polymerase alpha (author's transl)].Seikagaku. The Journal of Japanese Biochemical Society · 1980
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Aphidicolin is a tetracyclic diterpene antibiotic isolated from the fungus Cephalosporum aphidicola with antiviral and antimitotic properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. It is a specific inhibitor of DNA polymerase Alpha and Delta in eukaryotic cells and in some viruses (vaccinia and herpesviruses) and an apoptosis inducer in HeLa cells. Natural aphidicolin is a secondary metabolite of the fungus Nigrospora oryzae.
== References ==
Excerpted from Wikipedia’s “aphidicolin” article, available under the CC BY-SA 4.0 licence.