β-thujaplicin
Sign in to saveHinokitiol (β-thujaplicin) is a natural monoterpenoid found in the wood of trees in the family Cupressaceae. It is a tropolone derivative and one of the thujaplicins. Hinokitiol is used in oral and skin care products, and is a food additive used in Japan.
Research
257 papers- Hinokitiol ameliorates MASH in mice by therapeutic targeting of hepatic Nrf2 and inhibiting hepatocyte ferroptosis.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2025
- [Synergistic effect of β-thujaplicin and tigecycline against tet(X4)-positive Escherichia coli in vitro].Sheng wu gong cheng xue bao = Chinese journal of biotechnology · 2023
- β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells.Bioscience, biotechnology, and biochemistry · 2015
- Preventive effects of β-thujaplicin against UVB-induced MMP-1 and MMP-3 mRNA expressions in skin fibroblasts.The American journal of Chinese medicine · 2012
- β-Thujaplicin inhibits basal-like mammary tumor growth by regulating glycogen synthase kinase-3β/β-catenin signaling.Food & function · 2019
via PubMed
Article
18 sectionsContents
- History
- Natural occurrence
- Chemical synthesis
- Chemistry
- Ionophore
- Biological properties
- Safety
- Uses
- Skin and oral care products
- Insect repellent
- Food preservative
- Wood preservative
- Research directions
- Iron transport
- Cancer research
- See also
- References
- External links
Hinokitiol (β-thujaplicin) is a natural monoterpenoid found in the wood of trees in the family Cupressaceae. It is a tropolone derivative and one of the thujaplicins. Hinokitiol is used in oral and skin care products, and is a food additive used in Japan.
== History == Hinokitiol was discovered by a Japanese chemist Tetsuo Nozoe in 1936. It was isolated from the essential oil component of the heartwood Taiwanese hinoki, from which the compound ultimately adopted its name. Hinokitiol is the first non-benzenoid aromatic compound identified. The compound has a heptagonal molecular structure and was first synthesized by Ralph Raphael in 1951. Due to its iron-chelating activity, hinokitiol has been called an "Iron Man molecule" in the scientific media, which is ironic because Tetsuo is translated into English as "Iron Man". Taiwanese hinoki is native to East Asian countries, particularly to Japan and Taiwan. Hinokitiol has also been found in other trees of the Cupressaceae family, including Thuja plicata Donn ex D. Don which is common in the Pacific Northwest.