Apolipoprotein A1

Protein · UniProt

Apolipoprotein A-I

Gene

APOA1

Organism

Homo sapiens (Human)

Length

267 aa

Molecular mass

30,778 Da

Evidence

1: Evidence at protein level

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility

• High-Density Lipoproteins and Apolipoprotein A1.Sub-cellular biochemistry · 2020
• Apolipoprotein A1-Related Proteins and Reverse Cholesterol Transport in Antiatherosclerosis Therapy: Recent Progress and Future Perspectives.Cardiovascular therapeutics · 2022
• Apolipoprotein A1 and B.Clinics in laboratory medicine · 2006
• Asparagine endopeptidase cleaves apolipoprotein A1 and accelerates pathogenesis of atherosclerosis.The Journal of clinical investigation · 2025
• Apolipoprotein-A1 transports and regulates MMP2 in the blood.Nature communications · 2025

via PubMed

• ACTIVE_NOT_RECRUITING
  Relationship Between Serum Apolipoprotein Levels and Weight Loss in Patients Undergoing Sleeve Gastrectomy for Morbid ObesityYigit DUZKOYLU · NCT07325916
• PHASE4UNKNOWN
  Crossover of Higher Dose Statins in Patients With Low High-density Lipoproteins Cholesterol (HDLc)Oregon Health and Science University · NCT00736463
• NACOMPLETED
  Theobromine, Vascular Function and Intestinal apoA-I ProductionMaastricht University Medical Center · NCT02209025
• NATERMINATED
  Mendelian Reverse Cholesterol Transport StudyUniversity of Pennsylvania · NCT01782027
• PHASE1/PHASE2COMPLETED
  Safety and Efficacy of APL180 in Healthy Volunteers and Patients With Coronary Heart Disease (CHD)Novartis · NCT00568594
• PHASE1RECRUITING
  Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy VolunteersNational Heart, Lung, and Blood Institute (NHLBI) · NCT04216342

via ClinicalTrials.gov